The aim of this study was to assess the knowledge, attitude and practice of B.Sc. Pharmacy students about usage and resistance of antibiotics. This was a cross-sectional questionnaire-based study involving Pharmacy students. The results showed good knowledge of antibiotic use among students. The overall attitude of pharmacy students was poor.
Dr.Neenu Eldho, Dr.Sankar
FORMULATION AND EVALUATION OF APREPITANT ORAL DISSOLVING FILMS
The objective of the present research was to prepare and evaluate oral dissolving films (ODF) of Aprepitant. Different combinations of polymers and plasticizers were evaluated for optimizing the physical properties and the in vitro drug release. Initially eleven placebo formulations were prepared by using glycerol as plasticizer and another eleven formulations were prepared by using PEG 400 as plasticizer. The placebo films were subjected to various evaluation tests and based on the results; drug is incorporated into the optimized formulations. Drug loaded films were prepared and subjected to various physicochemical evaluations and in vitro dissolution studies. The drug-polymer incompatibility was ruled out by FTIR studies. From the FTIR studies, the drug-polymer compatibility was confirmed. All the films were shown satisfactory results which complies with official limits. The film prepared using HPMC E15 (F4) with 1:1 ratio of drug and polymer with glycerol as plasticizer were considered to have acceptable physical properties, disintegration time of below 60 sec and > 85% of drug release within 5 minutes and hence were considered as optimum.
Divya.L, Niranjan Babu.M
A REVIEW ON RISK FACTORS, INCIDENCE RATE AND MANAGEMENT OF URINARY TRACT INFECTION IN PAEDIATRICS
Urinary tract infection is a common bacterial infection causing illness in infants and children. It may be difficult to recognize urinary tract infections in children because the presenting symptoms and signs are non-specific, particularly in infants and children younger than 3 years. It is estimated that 3-7 out of every 100 children will have urinary tract infection. When urinary tract infection is diagnosed in a child, an attempt should be made to identify any risk factors for the urinary tract infection. Child with Urinary Tract Infection needs prompt antibiotic treatment in appropriate dosages to minimize kidney damage. A valid urine sample must be obtained before antibiotic therapy and this warrants a Supra Pubic Aspiration for infants and young children. Do not use urinary antiseptics for febrile Urinary Tract Infection. Assessing all the patients after 48 hours of therapy for clinical improvement is necessary
Thota Maduri, Dr. Robin
ANTI-ARTHRITIC ACTIVITY OF Annona reticulata Linn AGAINST FORMALDEHYDE INDUCED ARTHRITIC RAT MODEL
In recent years, natural products are becoming an important area of interest for the development of new therapeutic entities due to their high safety and low cost. The present investigation was examined for anti-arthritic activity of hydro alcoholic extract of Annona reticulata Linn against formaldehyde (0.1 ml of 2% v/v in normal saline) induced at sub plantar region of left hind paw during day 1 & day 3 of study period. The changes observed in paw diameter during the study period and serum biochemical parameters were significantly ameliorated upon treatment with test extract HAAR at both dose levels (200 & 400 mg/kg, b.wt., p.o) as compared to the standard treatment with aceclofenac (50 mg/kg, b.wt., i.p). It was concluded that hydro alcoholic extract of Annona reticulata Linn possess Antiarthritic activity.
HCV infection is one of the major causes of morbidity which affect about 3%of the population. Use of Interferon is the widely accepted therapy for HCV infection . Thyroid disease is a complication of this therapy which may lead to the discontinuing therapy. The cardiovascular risks in thyroid disease patient are coronary changes, cardiac output, cardiac contractility, vascular resistance and blood pressure. And all these cardiac changes are reversible with management of thyroid disease. So this study aims to assess the prevalence of cardiovascular risk in HCV infected patients treated with interferon exhibiting interferon induced thyroid disease. The study is conducted on some HCV patients in a tertiary hospital who were treated with interferon. The risk of cardiovascular events is assessed using Framingham risk score for 10 years. Finally the score is compared between patient taken interferon and those who didn’t. And the study resulted that Among 100 HCV patient treated with interferon ,37 develop clinical thyroid disease, 49 found thyroid antibody positive and 21of those shown cardiac risk according to Framingham risk score for 10 years.