Cardio protection means any activity that protects heart and preserves activities of heart and even prevents cardiovascular risk. Cardiovascular disease (CVD) includes coronary artery disease such as angina and myocardial infarction. Many diseases manifesting themselves in a different way actually underlie the cardiovascular problem. Herbal drugs derived from medicinal plants are known to exhibit creditable medicinal properties for the treatment of heart ailments and need to be explored to identify their potential application in prevention and therapy of human ailments. This review explains types and risk factors of CVD, different medicinal plants having cardio protective activity and mechanisms by which Artichoke showing its cardio protective activity
D. Swetha*1, K. Harika1, B. Preetha1, C. Vamsi Krishna1, R. Puzahenthi
DOCUMENTATION OF ACTIVITIES OF PHARM D STUDENTS IN INDIAN HOSPITALS
As the practice of pharmacy evolves, requiring more clinically oriented healthcare providers, Doctor of Pharmacy programs expand their training to more hospital sites to expose students to the provision of safe, effective, and economic drug therapy to patients. The need for this form of patient care becomes is essential in managing chronic illness like diabetes, hypertension, and other cardiovascular disorders. In all these conditions, the diseases are usually lifelong and with a number of co-morbidities, making polypharmacy part and parcel of the overall treatment strategy. The main objective is to maximize the clinical effects of medicines, i.e., using the most effective treatment for each type of patient; minimizing the risk of treatment-induced adverse events, i.e., monitoring the therapy course and the patient’s compliance with therapy trying to provide the best treatment alternative for the greatest number of patients
M. Manasa*, D. Swetha, S. Rihana begum, Ch. Manga Devi, R.J. Naveen Kumar, K. Venkatrao
STUDIES ON BIOSORPTION OF ZINC BY SELECTED MICROBES
Zinc is an essential and beneficial trace element in human growth; concentrations above 5mg/ml can cause a bitter astringent taste and opalescence in alkaline water. The zinc concentration of drinking water varies between 0.006 and 7mg/ml. Zinc most commonly enters the domestic water supply from the deterioration of galvanized iron and dezincification of brass. Over dose of zinc negatively influence human and animal health and over such a boundary concentrations zinc may even be toxic. So in this connection we tried an attempt to remove the zinc from water sample by using microbes as it is a ecofreindly. The efficiency of biosorption of zinc with three microbes Bacillus subtilis, Saccharomyces cerevisae, Aspergillus niger were estimated. Aspergillus niger have higher capacity to accumulate zinc when compared to Saccharomyces cerevisae and Bacillus subtilis. Hence Aspergillus niger was well suited for removal of zinc from contaminated water. However there are still many uncertainties associated with the development of treating waste water by living fungi and more future work is necessary.
Charumathi. S*, Lavanya. D, Harika. K, Varadharajan. K, P. Rajasekhar, Niranjan Babu. M
ESTIMATION OF VITAMIN-C AND PHYTOCHEMICAL SCREENING OF Brassica olerecea botrytis
Vitamin c (Ascorbic Acid) is an essential nutrient in humans as it functions as a cofactor in several vital enzymatic reactions plays an important role in collagen biosynthesis, iron absorption, and immune response activation and is involved in wound healing and osteogenesis, fights against free-radical induced diseases. Brassica species are very rich in health-promoting phytochemicals, including phenolic compounds, vitamin c, and minerals. It has a high content (20% or more of the daily value) of vitamin c. The main objective of this study is to determine the amount of vitamin c content present in different forms of brassica olerecea botrytis (cauliflower) florets such as dry powdered extract (maceration), boiled extract, and fresh extracts by using colorimetry. By the phytochemical screening of all the extracts it shows the presence of alkaloids, triterpenoids, flavanoids, saponins which posses many pharmacological acivities. From the colorimetric estimation of vitamin c for all the three extracts it is revealed that the aqueous crude extract (18 µg) posses more concentration of vitamin c than the boiled (5 µg) and dry extracts (3 µg).By this study it can be concluded that the intake of raw cauliflower florets that are rich in vitamin c than other boiled and dry extract will provide more beneficial effects to our body.
D. Lavanya*, Pranabesh Sikdar, M. Shankar, R. J. Naveen Kumar, D. Swetha, M. Niranjan Babu
In recent years, considerable attention has been focused on the development of novel drug delivery systems (NDDS). Osmotically controlled drug delivery systems (ODDS) are a type of NDDS which utilize osmotic pressure for controlled delivery of active agent(s). The release of drug(s) from osmotic systems is independent of gastric pH & gastric motility. The release of drug(s) from osmotic systems is affected by various formulation factors such as osmotic pressure of the core component(s), solubility and size of the delivery orifice, and nature of semi permeable membrane. Different types of osmotic systems have been developed implantable & oral. This review focuses on types of ODDS and factors affecting release of drug and various formulation factors from the systems
M. Hari Krishna*, Samriddhi Datri, P. Mahipal, M. Kumar, Koushik Sen Guptha, Subhasis Debnath
MICROSPONGES: FOR THE CONTROLLED RELEASE OF ACTIVE AGENTS
Microsponges are one of the novel drug delivery, which were originally developed for topical delivery of drugs. It is n unique technology recommended for the control release of macro pore bead loaded with active agent which is helpful to maintain therapeutic efficiency and there by helpful for the reduction of unwanted side effects with improved stability. These are patented polymeric delivery systems with contain porous microspheres design to entrapped active ingredients such as emollients, fragrances, essential oils , sunscreens and anti-infective, anti-fungal and anti-inflammatory agents. They are usually 5-300µm in diameter. It provides control delivery of oral medication to the lower gastro intestinal tract and colon specific drug delivery system. There are a lot of marketed products available for microsponge drug delivery system. The method of preparation involves liquid- liquid suspension polymerization, quasi emulsion solvent diffusion. Microsponges are used as sunscreens, anti-acne, anti inflammatory, anti fungal, anti pruritics and anti dandruff agents. They are characterized on the bases of particle size determination, scanning electron microscopy, loading Efficiency, true density and pore structure. It provides a wide range of formulating advantages. Some microsponge based products is likely to become a valuable drug delivery system for various therapeutic applications in the future
Harika. K*1, D. Swetha Debnath2, M. Harikrishna1, M. Kumar, G. Venkataramana, M. Niranjan Babu3
COMPARISON OF METFORMIN AND METFORMIN WITH OTHER ORAL HYPOGLYCEMIC AGENTS COMBINATION ON WEIGHT IN TYPE-2 DIABETES MELLITUS PATIENTS
Metformin is biguanide type oral hypoglycemic agent which reduces the body weight in type 2 diabetes mellitus patients. Metformin causes weight loss by reducing food intake. It primarily acts on the central nervous system to reduce appetite by attenuating hypothalamic AMPK activity, which decreases NPY (orexigenic) and increases POMC (anorectic) expression. It is a prospective, observational study to be conducted in RIMS hospital in the departments of General medicine. During the study period of six months, the total sample size was 78. The results obtained were significant for the metformin only used group (group A) of the males compared to the average weights of the females with P – value (P < 0.05). The study was not significant for other groups of the patients. The effects of the combined therapy of metformin and other oral antidiabetic drugs (sulfonylureas 1-2 mg/day) show the moderate weight gain. In the present study, we concluded that subjects who were treated with metformin induced weight loss. The study showed that 6 months of metformin monotherapy (500-1000 mg/day) caused a mean reduction in bodyweight of 2.34 kgs, The subjects who were treated with combination therapy (metformin + other oral hypoglycemic agents) caused moderate body weight gain 1.77 kgs. Without taking a calorie-restricted diet.
The World Health Organization (WHO) addressed drug utilization as the marketing, distribution, prescription and use of drugs in a society, considering its consequences, either medical, social, and economic. To determine the prescribing patterns of antimicrobial agents. To study commonly prescribed antibiotics in surgery department. To identify medication related problems & medication errors. To study about rational usage of antimicrobials. Surgical Unit-1 & Surgical Unit-2 in Sri Venkateswara institute of medical sciences Tirupati. The study is planned over a 6months period . Frequently used antimicrobial agents are Ceftriaxone 50 (12.5%) and Ciprofloxacin 40 (10%) and less frequently used antimicrobial agents are Colistin 03 (0.75%) and Azithromycin 05 (1.25%). most frequently used Antimicrobial combination are Amoxicillin+clavulanic acid 15(30%) and cefoperazone + salbactum 10 (20%) and less frequently used antimicrobial combination are Imipenum + cilastatin 03 (6%). Amoxicillin clavulanate was resistant to microorganisms in most of the cases (26.6%). Study on organisms prevailing and its sensitivity pattern of AMAs in the surgical department units will help the physicians to select the proper drug choice. .
T. Charan teja*, S. Sirisha, P. Prashanthi, B. Narasimhulu