Terbinafine HCl, an antifungal drug has poor water solubility. Widely used topical terbinafine HCl ointment, cream, lotion has many disadvantages. They have very sticky causing uneasiness to the patient when applied. Moreover they also have lesser spreading coefficient and need to apply with rubbing. In the present study, an emulgel system composed of water in oil emulsion was designed and developed to enhance the availability and efficacy of antifungal drug Terbinafine HCl when used topically. 0.5%, 1% and 1.5% concentrations of carbopol 934 as gelling agent were used to formulate the emulgels. Formulated emulgels were evaluated for physical appearance, viscosity, spreadability, pH etc. The effect of concentration of gelling agent on the in vitro release of terbinafine HCl was also studied. It has seen that formulation F1 which contains 0.5% w/w of carbopol shows 97.87% drug release, whereas formulation F2 shows 94.697 % drug release after one hour. The release of the drug from the emulgel formulation follows Fickian law.
The formulation and in-vitro evaluation of Metoprolol tartrate buccoadhesive tablets was carried out. The preformulation studies ensured a satisfactory purity of the drug candidate and its compatibility with sodium alginate and other excipients. Linearity in the calibration of Metoprolol tartrate was noticed between 1-25µg/ml ranges. Sixteen batches of Metoprolol tartrate bucco adhesive tablets were prepared (BT1 to BT16) and the effect of drug to polymer (sodium alginate) ratio, backing layer, compressional force, compression time, average weight, friability, drug content, muco adhesive strength and in-vitro drug release were evaluated. From the results obtained batch BT5 (1:2 drug polymer ratio) was selected as an ideal batch, as it exhibited a maximum mucoadhesive strength with minimum friability. A batch prepared with 1:2 drug to polymer ratio with 40mg ethylcellulose as backing layer, compressed at 6 tonnes/cm2 pressures for 10 seconds compressional time showed 13.3g mucoadhesive strength and 80.6% in-vitro drug release over a period of 6 hours. It was selected to be an ideal batch. The ideal batch of compressed buccoadhesive tablets was stable with respect to its physicochemical and in-vitro drug release performance over a period of two months at room temperature
Agilandeswari. D*1 and Sajani Raju2
ANTI-ULCER ACTIVITY OF Vateria indica Linn. RESIN IN VARIOUS EXPERIMENTAL ANIMAL MODELS
The aim of the present study was designed to evaluate the anti-ulcer activity of the aqueous extract of the resin of “Vateria indica” using various experimental animal models. Anti-ulcer activity was evaluated by using two animal models. The degree of antiulcer activity was determined by measuring the ulcer index in Ethanol induced and indomethacin induced ulcer models. Vateria indica resin extract in the higher dose (500mg/kg) witnessed a significant dose dependant anti-ulcer activity against ethanol induced gastric ulcer and indomethacin induced gastric ulcer models. It also produced a significant (**p≤0.01) reduction in the ulcer index on higher dose (500mg/kg) as well as standard (Ranitidine) treated groups. The study revealed that Vateria indica Linn. resins extract posses significant anti-ulcer activity.
Satish. S1 and Mohammed Nuhman*1
A STUDY ON ANTICONVULSANT ACTIVITY OF AQUEOUS EXTRACTS OF FRESH LEAVES OF Ruta chalepensis Linn. IN EXPERIMENTAL ANIMAL MODELS
The aim of the present study was designed to evaluate the anticonvulsant activity of the aqueous leaf extract of Ruta chalepensis Linn. in various experimental animal models. Anticonvulsant activity was evaluated by using two animal models. The degree of anticonvulsant activity was determined by measuring the onset and duration of seizure in strychnine induced convulsion and Isoniazid induced convulsion models. Animals treated with all three doses of RCL (250,500 and 750mg/kg) witnessed a significant delay in the onset on seizure in SIC & IIC which was significant when compared with control. The study revealed that the Aqueous leaf extract of Ruta chalepensis Linn. Posses significant anticonvulsant activity.
Satish. S1 and Abdul Kareem. M*1
DEVELOPMENT OF A RAPID LIQUID CHROMATOGRAPHIC METHOD FOR THE ANALYSIS OF STARTING MATERIAL (2, 3-DIBROMO-5-BENZOYL PYRROLE) IN KETOROLAC TROMETHAMINE
A high performance of liquid chromatographic (HPLC) method for the analysis of impurity in ketorolac tromethamine. The chromatographic separation was achieved on a phenomenex C18, 150 × 4.6 mm, 5µ column at a detector wavelength of 320 nm and a flow rate of 1.0 ml/min. The mobile phase was composed of phosphate buffer ( 0.29 ml of ortho phosphoric acid (88%) in 500 ml of double distilled water) and acetonitrile (50:50 v/v). The retention of 2,3-dibromo-5-benzoyl pyrrole was 11.90 min. This method can be used for the routine quality control and assay of starting material (2 ,3-dibromo-5-benzoyl pyrrole) in ketorolac tromethamine in pharmaceutical preparation.
Chandra sekhar. R*1, Venkataramana. G, Niranjan babu. M